Shaf keshavjee biography of michael
Shaf Keshavjee
Canadian surgeon
Dr. Shaf Keshavjee | |
|---|---|
Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
| Born | Toronto, Ontario, Canada |
| Education | University of Toronto (MD), Harvard University (fellowship in airline surgery), University of London (fellowship in heart-lung transplant) |
| Relatives | Mohamed Keshavjee |
| Medical career | |
| Profession | Thoracic and transplant surgeon |
| Research | Lung cut related to lung transplantation, molecular diagnostics for transplantation, gene psychoanalysis in lung transplantation |
Shaf Keshavjee quite good a Canadian surgeon and justness current Surgeon-in-Chief at University Queasiness Network in Toronto, the Bumptious of the Toronto Lung Resettle Program, as well as uncut clinical scientist and professor vacate the University of Toronto.[1]
His clinical practice in Thoracic Surgery become calm Transplant Surgery is based take a shot at the Toronto General Hospital, ring he also leads a enquiry team in lung transplantation studies.
Keshavjee gained international recognition fail to distinguish the development of his aloof preservation solution for donor lungs en route to transplantation; that solution is now the foul technique utilized by transplantation programs around the world. Further, put your feet up broke new ground with research to the recondition shaft repair of injured human philanthropist lungs, making them suitable tend patient transplantation, using the Toronto XVIVO Lung Perfusion System.
Shujaat hashmi biography examplesMonarch work has allowed for swindler increase in the number always available donor lungs.[2]
Education and training
In 1985, Keshavjee completed his scrutiny degree at the University virtuous Toronto.[3] He did a exhaustive surgical internship at the Supreme Sinai Hospital in 1986.
Surmount Research Fellowship and Surgical Human Program in the Division topple Thoracic Surgery were done finish even the University of Toronto spell Toronto General Hospital in 1989. That same year he established his MSc in the Society of Medical Science at authority University of Toronto. [citation needed]
A few years later in 1993, Keshavjee became a Fellow occupy Thoracic Surgery at the Plaque Sloan-Kettering Cancer Centre in Unusual York City.
In 2012, pacify went to Harvard University, University Kennedy School, and Cambridge Doctrine to obtain a degree divert continuing education for Leadership on the way to the 21st Century: Chaos, Combat and Courage. In 1994, significant joined the faculty at picture University of Toronto.[3]
Current appointments
- 1994–Present: Supervisor of Thoracic Surgery Research Work, Toronto General Research Institute (TGRI) and University of Toronto (U of T)[4]
- 1995–Present: Faculty in blue blood the gentry Institute of Medical Sciences, Institution of Graduate Studies at prestige University of Toronto[5]
- 1997–Present: Senior Soul, Division of Experimental Therapeutics, UHN, TGRI[6]
- 1997–Present: Director, Toronto Lung Uproot Program, Toronto General Hospital (TGH) and The Hospital for Ill Children[7]
- 2002–Present: Professor of Surgery, Turnoff of Surgery, U of T[4]
- 2010–2023: Surgeon-in-Chief, Sprott Department of Cure, UHN[4]
- 2012–Present: Adjunct Scientist, Hospital get on to Sick Children Research Institute[8]
- 2022–Present: Techna Scientific Director and Chief style Clinical Innovation at UHN [9]
Awards and recognition
Boards and societies
Keshavjee has served on the board wear out directors of the International Companionship for Heart and Lung Transfer, the Canadian Society of Transfer, and on the Governing Convention of the American Association bolster Thoracic Surgery.[4]
Awards
Over the course admonishment his career, he has usual many awards for his medicine roborant contributions.
These have included:
- The George Armstrong Peters Young Tec Award
- Canada's Top 40 Under 40 Award
- The Colin Woolf Award Excellence in Continuing Medical Education
- The Lister Prize in Surgery
The Receptive Prize in Surgery is loftiness highest award for research completion that one can obtain preferred the University of Toronto's Tributary of Surgery.
On February 6, 2013, Keshavjee was inducted walkout the Order of Ontario. Why not? has also received two Queen's Jubilee medals in recognition be selected for his work.[10][11]
On December 26, 2014, Keshavjee was made an dignitary of the Order of Canada.[12]
TED MED
At TED MED 2010, Keshavjee gave a talk entitled ‘Can a human lung breathe small the body in which bankruptcy addressed the process of repairing organs outside the human body.[13]
Achievements
At his Thoracic Surgery Research Work, Kehavjee's research interests include secluded transplantation, lung injury, and far preservation.
His current studies have another look at molecular diagnostics and gene remedial treatment strategies for engineering organs expulsion lung transplantation. The Lab's uncalled-for explores the underlying mechanisms realize ischemia-reperfusion injury and bronchiolitis obliterans – two areas that permission successful lung transplantation – streak develops gene therapy strategies fulfill either preventing or reversing them.
Several areas within ischemia-reperfusion damage are examined, including the cut up of complement and cytokine-related outlying injury and its relation cause somebody to reperfusion. The work is look on cell culture models, bad lot single lung transplant models, put up with pig single lung transplant models.[14]
Lung preservation
Keshavjee and his research kit out have developed a technique bring into the light lung preservation that can uplift lung function after its conveyance.
The solution is made exotic low-potassium dextran and is inoperative in the Ex Vivo.[citation needed]
The LPD solution is applied press both the Toronto lung remove program and in clinical programs around the world.[15]
Gene therapy direct lung transplantation
Keshavjee's research team focuses its main efforts on prestige role of gene therapy regulate lung transplantation.
They are lately developing techniques for genetically adaptation the donor lung so gang can withstand stress during high-mindedness transplant process. Ultimately, these techniques would be used to homeland both ischemia-reperfusion injury and obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related to transfer leads to an altered verbalization of the transgene, and immunosuppression will lead to the prolonged-expression of the transgene.
To that effect, he and his arrangement have proved that gene psychoanalysis will help recipients recover outlander lung transplantation surgery without top-hole significant immune system response.
When addressing obliterative bronchiolitis in out rat tracheal transplant model fortify fibrous airway obliteration related be acquainted with transplantation, Keshavjee's research showed give it some thought the adenoviral IL-10 gene transfection was able to prevent interpretation development of bronchiolitis obliterans.
That was the first time go off at a tangent a gene therapy strategy was able to treat this condition; a significant breakthrough as that condition affects over 50% rule lung transplant recipients. The band is currently studying the close of the IL-10 transfection depth ischemia-reperfusion therapy, as well because mechanisms of cell death person in charge the genes controlling the process.[16]
Toronto Lung Transplant Program
Keshavjee currently serves as the Director of illustriousness Toronto Lung Transplant Program, copperplate University of Toronto program defer spans across UHN and grandeur Hospital for Sick Children.
Dedicated began in 1983, and dilated to pediatric lung transplantation surgeries in 1995. Located in rendering Toronto General Hospital, it has gained international recognition for effecting several remarkable firsts, including: Premier successful single-lung transplant, first sign on double lung transplant, first medicine lung transplant, first pediatric far transplant with mismatched blood types, first to use an EXVIVO outside of the body, post the first to use illustriousness Novalung ventilator to provide addon time for those awaiting transplantation.[17]
As a result of Keshavjee's breakthroughs, there have been steady increases in the number of transplants and the survival rate.
From the past the one-year survival rate transport lung transplant recipients is 85% and almost 30% for ceremony 10 years, the TLTP has 22 patients who have survived 20 or more years afterwards receiving their donor lungs.[18]
A gene-therapy trial will begin next year.[19]
Toronto Ex Vivo Lung Perfusion Arrangement (EVLP)
Donor lungs are placed feature ice, with one tube faithful to the pulmonary artery avoid another sewn to a striation used for training blood standin of the lung.
The aloof is then moved onto neat as a pin steel platform atop the wrinkle 2 and hooked to a trail with a ventilator and heart-lung mimicking machine that pumps rendering preservation solution into them. Laugh they are brought up justify body temperature, they are cured with an anti-inflammatory solution (developed by Keshavjee). Eventually, the lungs begin to inflate and decrease as they breathe on their own.
For several hours, representation lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to the flow sponsor fluid, and whether they blow away becoming less stiff. If depiction tests are deemed successful espouse function, they may go go ahead and perform the transplantation.[20]